Normalization of methotrexate-induced high levels of serum transaminases after ursodeoxycholic acid administration in a rheumatoid arthritis patient

Normalization of methotrexate-induced high levels of serum transaminases after ursodeoxycholic acid administration in a rheumatoid arthritis patient SIR, Administration of ursodeoxycholic acid (UDCA) can improve liver function in the course of several hepatic

inflammatory process improves, FDG uptake should be diminished, at least in the affected vessels. This was confirmed in the two patients for whom we have a follow-up F18-FDG-PET. Nevertheless, this pathophysiological basis can cause some false-positive results, as FDG uptake can occur in atherosclerotic lesions with an accumulation of inflammatory cells. Usually these images are less clearly po...

Methotrexate-induced hyperpigmentation in a rheumatoid arthritis patient.

Exacerbation of rheumatoid arthritis in patients treated with methotrexate after administration of folinic acid.

A double blind, placebo controlled trial examined the effects of folinic acid on the efficacy and toxicity of methotrexate in 27 patients with rheumatoid arthritis. Clinical and laboratory indices of disease activity worsened significantly in the 13 patients treated with folinic acid after four weeks of treatment, but not in the 14 patients treated with placebo. Exacerbation of rheumatoid arthr...

A Case of Acute Myeloid Leukemia Caused by Low Dose Methotrexate Used to Treat a Rheumatoid Arthritis Patient

Methotrexate is an anti-rheumatic agent used as a first-line tretment for rheumatoid arthritis. Hematological malignancies like lymphoma or acute myeloid leukemia have been reported to be secondary to treatment with Methotrexate, but are very uncommon. We report here the first Moroccan case of RA patient on low dose MTX, who developed AML. We also reviewed all similar cases.

The effect of combined antioxidant supplement on serum lipids levels in female Patients with rheumatoid arthritis

Background: Rheumatoid arthritis (RA) is one of the autoimmune diseases with unknown etiology that its prevalence in females to males is 3 to 1. This disease has positive relationship with occurrence of atherosclerosis and cardiovascular diseases are taken into account for 50% of death in RA. Regarding the recent researches, antioxidant supplements may have important role in serum lipids reduct...